Failed to create com object

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Hello,
here is my issue: I installed VirtualBox 2.2 on my PC, but when I start it for the first time, an error message appears saying "Failed to create the COM object."
I don't understand where this could come from; I installed it on both XP and Vista and have the same problem :s
Do you have any idea?

Here is the error message on Vista ==> http://pics.imagup.com/02/1239945107_Sans titre-1.jpg
Configuration: Windows Vista Firefox 2.0.0.20

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